Study of the Clinical Scoring System and Cytokines for Prediction of Inflammatory Response in Major Surgery

Prediction for Systemic Inflammation With Clinical Scoring Systems and Inflammatory Cytokine Levels in Adult Cardiac and Major Abdominal Surgical Patients

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01353157

Enrollment

Registered

2011-05-12

Start date

2010-03-31

Completion date

2010-12-31

Last updated

2011-05-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cytokine Release Syndrome, Heart; Dysfunction Postoperative, Cardiac Surgery

Keywords

cytokine, cardiac surgery, clinical scoring system

Brief summary

Cardiac surgery with cardiopulmonary bypass (CPB) and hepatic surgery are major operations, associated with a systemic inflammatory response syndrome. The aim of this study is to assess the effectiveness of clinical scoring systems and inflammatory cytokine levels for predicting systemic inflammation. This correlation might identify peri-operative clinical outcomes, then forecast further systemic inflammation in cardiac and hepatic surgical patients.

Detailed description

Systemic inflammatory response syndrome (SIRS) is commonly found in most major surgery. Early detection of SIRS will lead to early treatment. Serum cytokines levels are reliable markers for SIRS detection but with high cost and inconvenience. Clinical Scoring Systems are commonly used for assessment of patients with SIRS. If they have good correlation with cytokine levels, they might be used to predict peri-operative clinical outcomes.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* adult patients who had undergone elective cardiac surgery with CPB

Exclusion criteria

* under 18 years of age * needing emergency surgery * needing intra-aortic balloon pump

Design outcomes

Primary

Measure	Time frame	Description
Correlation of clinical scoring systems and inflammatory cytokine levels	24 h after CPB	Blood samples were collected sequentially at 0, 0.5, 4, 12, and 24 h after CPB for cytokines \[Interleukin (IL)-6, IL-8, and IL-10\] investigation and leukocyte counts. Clinical scoring systems \[Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA) and Multi-Organ Dysfunction (MOD)\] were calculated and recorded at each time point. Correlations were assessed.

Countries

Thailand

Outcome results