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Effects of Massage Versus Rest on Hormones

Investigating the Effects of Massage vs. Rest on Oxytocin, ACTH, and B-endorphins

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT01351402
Enrollment
95
Registered
2011-05-10
Start date
2006-06-30
Completion date
2007-01-31
Last updated
2011-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Massage, Rest

Keywords

Massage, Rest

Brief summary

This study will investigate the effects of 15 minutes of massage compared to 15 minutes of quiet rest on physiological variables. Specifically, the investigators will measure the effects on levels of the social hormone oxytocin, and on other physiological variables that interact with oxytocin or that may be influenced by massage (including ACTH, Beta-endorphin, and IL-1alpha). The investigators will also investigate whether, in the case of hormones changes, these influence social decision making.

Detailed description

Interested participants will have the experiment explained both verbally and in writing, and asked to give their informed consent in writing. After consent, the participants will be led to a private room for their first 30ml blood draw by a qualified phlebotomist. Participants will then have a second 30ml blood draw.

Interventions

PROCEDUREMassage or Rest

Participants either received 15 minutes of moderate pressure Swedish massage on the upper back, or rested quietly sitting in a chair for 15 minutes.

Sponsors

Gruter Institute
CollaboratorUNKNOWN
Claremont Graduate University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Primary purpose
BASIC_SCIENCE
Masking
SINGLE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* Anyone English speaking and over the age of 18.

Exclusion criteria

* Minors and anyone who has used illicit drugs or alcohol in the last 24 hours.

Design outcomes

Primary

MeasureTime frameDescription
OxytocinWithin 5 minutes following experimental manipulation of either 15 minutes massage or rest.Participants receive a blood draw at baseline and immediately following 15 minutes of massage or rest and oxytocin will be measured from this sample.

Secondary

MeasureTime frameDescription
Adrenocorticotrophic hormone (ACTH)Within 5 minutes following experimental manipulation of either 15 minutes massage or rest.Participants will receive a blood draw at baseline and immediately following 15 minutes of massage or rest, and ACTH will be measured in these blood samples.
Beta-endorphinWithin 5 minutes following experimental manipulation of either 15 minutes massage or rest.Participants will receive a blood draw at baseline and immediately following 15 minutes of massage or rest, and B-endorphin will be measured from these samples.
Interleukin-1alpha (IL-1a)Within 5 minutes following experimental manipulation of either 15 minutes massage or rest.Participants will receive a blood draw at baseline and immediately following 15 minutes of massage or rest, and IL-1a will be measured from these samples.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026