The Effect of Eggs on Postprandial Metabolism

The Effect of Eggs on Postprandial Metabolism: A Randomized, Controlled Crossover Pilot Study in Older, Overweight Adults

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01351207

Enrollment

Registered

2011-05-10

Start date

2011-04-30

Completion date

2014-08-31

Last updated

2014-11-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

The objective of this randomized, double-blinded, placebo-controlled, 3-way crossover pilot study is to determine whether eggs can favorably alter biomarkers of postprandial metabolism when included with other cooked breakfast foods typically selected by older Americans.

Interventions

OTHEREggs

Comparison of a high saturated fat/low fiber meal alone, with eggs, and with a protein/cholesterol matched egg-free pudding

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

50 Years to 70 Years

Healthy volunteers

Yes

Inclusion criteria

* Men & postmenopausal women, aged 50-70 years * BMI 28-34 kg/m2

Exclusion criteria

* Cigarette smoking and/or nicotine replacement use * Individuals taking estrogen * Use of cholesterol-lowering medications * Use of blood pressure-lowering medications * Regular use of any stomach acid-lowering medications or laxatives (including fiber supplements) * Cardiovascular (heart) disease * Gastrointestinal disease * Kidney disease * Endocrine disease: including diabetes, untreated thyroid disease * Rheumatoid arthritis * Active treatment for any type of cancer, except basal cell carcinoma, within 1 year prior to study admission * Systolic blood pressure \> 150 mmHg and/or diastolic blood pressure \> 95 mmHg * Regular use of oral steroids * Regular daily intake of ≥ 2 alcoholic drinks * Vegetarians * Allergy to eggs * Avoidance and/or intolerance of pork products * No dietary supplements, including those containing any vitamins, minerals,herbs, plant concentrates (including garlic, gingko, St. John's wort) homeopathic remedies, probiotics, or fish oil (including cod liver oil), for one month prior to study admission

Design outcomes

Primary

Measure	Time frame	Description
Postprandial change in blood glucose concentration compared to placebo	0-4 h	Biomarkers of glucoregulation and insulin sensitivity, inflammation, lipid peroxidation, antioxidant activity, and satiety hormone production will be assessed in blood and urine

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026