Alzheimer's Disease
Conditions
Brief summary
Amyloid plaques and neurofibrillary tangles are the 2 well-known etiopathological hallmarks of Alzheimer's disease (AD). Beside these 2 lesions, inflammation response is described in the brain of patients with AD. The main objective of our study is to analyse the correlation between the value of plasma cytokines (interleukin 1, 6, TNFα and chemochine Rantes) and the rapidity of the cognitive decline in AD over a 2-year follow-up. Secondary objectives include: * the predictive value of the cytokines on the cognitive decline after 6 months and one year of follow-up., of the patients include 150 patients with AD (MMSE: 16-25) * correlation between plasma cytokines levels and expression of the protein kinase PKR (involved in death cell) in blood mononuclear cells.
Interventions
OTHERblood test and cognitive tests
Specific cognitive tests are performed at day 1, month 6, one year and 2 years Specific Blood samples tests are performed at inclusion, 1 years and 2 years
Sponsors
Poitiers University Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Alzheimer's disease (AD)patients * MMSE score: 16-25 * Written informed consent
Exclusion criteria
* AD patients with specific treatment for AD before inclusion MMSE score under 16 or over 25 at inclusion * patients with anti-inflammatory drugs (non steroids or corticosteroids) or immunosuppressive agents * Patients with acute disease (infectious disease, rheumatologic disease) or chronic disease (malignancy, infectious, rheumatologic disease) that could interact with plasma cytokines level * Patients with a life threatening disease
Countries
France
Outcome results
None listed