The Counter-irritating Efficacy of Topical Povidone-iodine in Thermal Burns

Testing the Counter-irritating Efficacy of Topical Povidone-iodine in Thermal Burns; Comparison to Conventional Treatments

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01350713

Enrollment

280

Registered

2011-05-10

Start date

2011-07-31

Completion date

2013-07-31

Last updated

2011-05-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Skin Burns

Keywords

skin, burn, povidone iodine, cold water

Brief summary

Skin burns are one of the causes of disability, suffering and death in humans. Anecdotal, uncontrolled studies have shown the efficacy of povidone-iodine ointment in human skin burns, provided the preparation was applied shortly after the exposure to the heat source. The proposed study will conduct a controlled study in which the effect of povidone-iodine ointment will be tested in large group of patients and will be compared with standard cold water treatment.

Detailed description

Skin burns are one of the causes of disability, suffering and death in humans. The current treatment includes application of cold water or other plant origin preparations. However non of these treatments was shown to be efficacious. Animal studies have demonstrated the pronounced protective effect of povidone-iodine ointment against thermal burns. Moreover, anecdotal, uncontrolled studies in humans have shown the efficacy of povidone-iodine ointment in human skin burns, provided the preparation was applied shortly after the exposure to the heat source. The proposed study will conduct a controlled study in which the effect of povidone-iodine ointment will be tested in large group of patients and will be compared with standard cold water treatment.

Interventions

DRUGpovidone iodine

one local application of 10% povidone iodine ointment

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

6 Months to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* skin burns in children

Exclusion criteria

* allergy to iodine

Design outcomes

Primary

Measure	Time frame	Description
prevention of skin lesions caused by exposure to heat source	1 year	Skin exposed to hot liquid or metal that topically treated with povidone-iodine will show no or slight irritation while individuals treated with the standard cold water will show strong skin irritation including erythema and blisters.

Secondary

Measure	Time frame	Description
scar prevention	1 year	povidine treated individuals no scar will develop. standard cold water treated patients may develop skin lesions(scars)

Countries

Israel

Contacts

Primary ContactArieh Bahir, MD

abahir@clalit.org.il0544-522877

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026