Healthy
Conditions
Keywords
leucine supplementation, BCCA supplementation, resistance exercise-induced muscle remodeling
Brief summary
This study aims to evaluate the effects of leucine and branched-chain amino acids supplementation on skeletal muscle remodeling signaling pathways induced by resistance exercise.
Interventions
DIETARY_SUPPLEMENTLeucine supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 5.6 g of alanine
DIETARY_SUPPLEMENTBCAA supplementation
1 bout of resistance exercise and supplementation of 4.0 g of leucine + 2.8 g of isoleucine + 2.8 g of valine
DIETARY_SUPPLEMENTAlanine supplementation
1 bout of resistance exercise and supplementation of 9.6 g of alanine
Sponsors
University of Sao Paulo
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Sedentaries * Must be able to exercise * Must be able to swallow tablets
Exclusion criteria
* Use of nutritional supplements * Use of anti-inflammatory drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Protein synthesis | 1 hour | Phosphorylation of proteins involved in protein synthesis |
| Protein degradation | 1 hour | Expression of protein involved in proteolytic pathway |
| Inflammation | 1 hour | Expression of systemic and muscular cytokines |
Countries
Brazil
Outcome results
None listed