Gastric Emptying, Diabetes Mellitus
Conditions
Keywords
Antioxidants, Glucose Intolerance prevention and control, Diabetes Mellitus prevention and control
Brief summary
The purpose of this study is to determine whether 3 g cinnamon was sufficient to delay the gastric emptying rate of a high-fat solid meal and subsequently reduce postprandial blood glucose and lipid responses, oxidative stress, arterial stiffness and satiety responses in a healthy adult population.
Detailed description
Cinnamon has been shown to delay gastric emptying (GE) of a high-carbohydrate meal and reduce postprandial glycaemia in healthy adults. However, it is dietary fat which is implicated in the etiology and is associated with obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD). We aimed to determine the effect of 3 g cinnamon on GE, postprandial lipemic and glycemic responses, oxidative stress, arterial stiffness, as well as appetite sensations and subsequent food intake following a high-fat (HF) meal. The effect of acute oral administration of 3 g cinnamon on gastric emptying of a high-fat pancake test meal and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially. During this time course, measurements of postprandial lipemic, glycemic, oxidative stress and arterial stiffness responses will be collected. Subsequently, food intake will be measured using an ad libitum buffet meal. The study will be conducted in a randomized, placebo-controlled, single-blinded manner in 9 healthy subjects.
Interventions
DIETARY_SUPPLEMENTCinnamon
acute oral administration of 3 g cinnamon
DIETARY_SUPPLEMENTPlacebo control
3 g wheat flour (placebo)- separated by 28 days from cinnamon intervention
Sponsors
University of Ulster
Ulster Hospital, Northern Ireland
National University of Ireland, Galway, Ireland
University of Limerick
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy adults aged 18-35 years * Recreationally trained individuals (participate in at least 2hrs/wk of individual/team sport) * Not currently taking antioxidant or lipid-lowering medication * Fasting blood lipid, glucose and blood pressure (BP) levels were all within the normal limits.
Exclusion criteria
* History of gastrointestinal-related conditions, diabetes mellitus or cardiovascular disease. * Allergies to foods in study. * Blood disorder * Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of 3grams cinnamon on gastric emptying half time | During the 6.5 hours post ingestion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lipaemia | During the 6.5 hours after ingestion | Plasma concentration (mmol/l) of triacylglycerols, LDL, and HDL will be measured every hour in the post-prandial period. |
| Glycemia | During the 6.5 hours after ingestion | The concentration of plasma glucose (mmol/l) will measured hourly in the postprandial period, using venous blood drawn from a forearm vein. |
| Arterial stiffness | During the 6.5 hours after ingestion | Post-prandial changes in pulse wave velocity (m/s) will be measured non-invasively, using Pulsetrace PSA2 to indicate arterial stiffness. |
| Oxidative stress | During the 6.5 hours after ingestion | Serum lipidhydroperoxides will be measured using FOX-1 assay. |
| Food intake | 6 hours post-prandially | A buffet meal will be presented to the volunteer 6h after breakfast. Food intake will be monitored covertly by weighing individiual food items before and after presentation. Food intake will be expressed as macronutrient (carbohydrate, fat, protein, water, fibre) and energy intake. |
| Appetite | During the 6.5 hours after ingestion | Subjective sensation of hunger, desire to eat, fullness, thirst, tiredness and coldness will be meaured using a 150mm visual analogue scale (mm). |
Countries
Ireland
Outcome results
None listed