Glucose Intolerance, Overweight/Obesity, Sedentarity, Type 2 Diabetes
Conditions
Keywords
Obesity, Type 2 diabetes, glucose intolerance, Physical Activity, Inflammation, HPA axis, Cytokines
Brief summary
The incidence of type 2 diabetes is increasing worldwide. Because of cardiovascular morbidity and mortality associated with type 2 diabetes, it is imperative to propose methods of prevention and this in early stage of abnormal glucose metabolism. This study will assess the beneficial effects of physical activity (acute and chronic effects) (the subjects being their own controls) on cardiometabolic and inflammatory biomarkers in 3 conditions : unstimulated (fasting and resting conditions) and stimulated conditions: postprandial response to a standardized meal preceded or not by an exercise bout. The investigators hypothesized that an acute bout of exercise will decrease the postprandial inflammatory response to a standardized meal and that this effect of exercise will be increased after 3 months of exercise training.
Detailed description
This is a prospective study over 4 months, open, nonrandomized. 45 overweight or obese male subjects will complete 3 experimental sessions (0700-1400h) before and after 3 months of supervised physical training. During a first session, subjects will remain inactive and fasted (basal conditions). During the second session a standardized meal will be offered (postprandial response to a standardized meal). The third session will consist in the realization of an exercise bout (60min at 60%VO2 max) followed by a standardized meal (same meal that the previous day). Several blood (catheter), salivary and urinary samples will be collected during the 3 sessions, throughout the experimental day.
Interventions
BEHAVIORALBehavior: Supervised physical training
protocol designed to evaluate effects of physical activity on cardiometabolic and inflammatory biomarkers according to glucose tolerance
Sponsors
Centre de Recherche en Nutrition Humaine d'Auvergne
University Hospital, Clermont-Ferrand
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
MALE
Age
30 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Male Caucasian Adults between 30 and 65 years old Sedentary criteria based on the determination of fasting glucose (WHO 1999): * normal if fasting plasma glucose (FPG) \<1.10 g / l * diabetes if fasting glucose\> 1.26 g / l (7 mmol / l) twice * nondiabetic fasting hyperglycemia: 1.10 g / l ≤ FPG ≤ 1.26 g / l * glucose intolerance : if plasma glucose at 120 minutes during the OGTT (75g) is between 1.40 g / l and 2 g/ l. Body mass index 25 BMI 35kg/m2 Affiliated to National Health Insurance Subject giving his written informed consent Subject considered as normal after clinical examination and medical questionnaire
Exclusion criteria
* \- drugs that interfere with the parameters determined * diabetic treated with insulin, glitazones or glinides * eating disorders like bulimia and vomiting * special diet, vegan or vegetarian * autoimmune disease or inflammatory progressive desease requiring prolonged treatment * regular physical activity (\> 1 hour of physical activity per week for at least 6 months) * smoking (\> 5 cigarettes / day) * weight change greater than 5% of the total weight in the 3 months preceding the study * contra-indication to physical activity * chronic pathologies: cancer, inflammatory, cardiac, pulmonary, renal, gastrointestinal or liver diseases * Being in exclusion on the National Volunteers Data file * No one under guardianship or not subject to social security. * Being under someone's supervision * Subjects deprived of their liberty by judicial or administrative. * Refusal to sign the information sheet and written consent for particip
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| supervised physical training on cardiometabolic and inflammatory biomarkers | after 3 months |
Secondary
| Measure | Time frame |
|---|---|
| relationships between cortisol secretion and the postprandial inflammatory responses depending on the level of glucose tolerance | after 3 months |
Outcome results
None listed