Postoperative Pain
Conditions
Keywords
postoperative, pain score, morphine consumption
Brief summary
The purpose of this study is to determine whether transdermal fentanyl patch
Detailed description
Total knee arthroplasty (TKA) has severe postoperative pain that prevents mobilization of patient. The best standard analgesia regimen is patient-control analgesia (PCA) which requires a PCA pump that is expensive. Transdermal fentanyl patch (TFP)(50 mcg/hr) can release fentanyl into blood circulation at rate 50 mcg/hr for three days. It has slow onset of about 12-14 hours, so it's used to treat chronic pain, not popular for a cure of pain. If the investigators apply TFP at appropriate times, i.e. 12-14 hours before surgery, it may be used to treat acute postoperative pain. If it can give good analgesia for TKA, it can replace PCA. The benefit is that it is much cheaper and more convenient.
Interventions
TFP = transdermal fentanyl patch (50 microgram/hour)
DRUGplacebo patch
group 2 = placebo patch
Sponsors
Khon Kaen University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients who were scheduled for TKA gave informed consent for inclusion
Exclusion criteria
* ASA class 3-4 * Known allergy to any of the drugs to be used, eg. TFPs ,MO * History of substance or alcohol abuse, and tolerance or dependence on opioids * Can not use PCA * Contraindication for spinal anesthesia
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intravenous morphine consumption | 48 hours |
Secondary
| Measure | Time frame |
|---|---|
| Pain score | 48 hours |
Countries
Thailand
Outcome results
None listed