Effect of 10mg Domperidone on Gastric Emptying of a High-fat Meal and Appetite Sensations in Healthy Adults

Does Domperidone, a D2-antagonist Alter Gastric Emptying Rates and Appetite Sensations in Healthy Adults?

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01347814

Enrollment

Registered

2011-05-04

Start date

2008-02-29

Completion date

2010-04-30

Last updated

2011-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus

Keywords

Domperidone, gastric emptying, obesity, diabetes mellitus, Domperidone/pharmacology, Pharmacologic Actions, Physiological Effects of Drugs, Gastrointestinal Agents, Humans

Brief summary

The purpose of this study is to determine whether domperidone was sufficient to accelerate gastric emptying of a high-fat solid meal and reduce satiety responses in a healthy adult population.

Detailed description

This study aims to investigate the effect of domperidone on gastric emptying and appetite sensations in healthy subjects. Domperidone is a dopamine 2 (D2) receptor antagonist with claims of gastrointestinal tract pro-kinetic activity. Accelerated gastric emptying (GE) may lead to reduced satiation, increased food intake and is associated with obesity and diabetes mellitus. It is hypothesized that domperidone will increase gastric emptying rate and reduce satiety responses to a high-fat meal. The effect of acute oral administration of 10 mg domperidone on gastric emptying of a high-fat pancake test meal, and subjective appetite sensations by visual analogue scale will be measured for six hours postprandially in a randomized, placebo-controlled, single-blinded manner in 13 healthy subjects.

Interventions

DRUGDomperidone 10mg

10mg domperidone tablet 30 minutes before a test-meal.

DRUGPlacebo

Homeopathic (Sugar) pill-Placebo

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

BASIC_SCIENCE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

10 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Healthy adults aged 18-40 years

Exclusion criteria

* History of gastrointestinal-related conditions, diabetes mellitus or cardiovascular disease

Design outcomes

Primary

Measure	Time frame	Description
Gastric emptying half time	6.5 Hours post ingestion	Determination of Gastric emptying of a high-fat test meal measured by octanoic acid breath test after acute administration of 10mg domperidone

Secondary

Measure	Time frame	Description
Appetite sensations	6.5 hours post ingestion	Determination of appetite sensations associated with ingestion of a high-fat test meal by visual analogue scale after acute administration of 10mg domperidone

Countries

Ireland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026