Chronic Renal Insufficiency, Renal Failure
Conditions
Keywords
Renal failure, Respiratory muscles, Resistance training
Brief summary
This study will investigate whether inspiratory muscle training in patients with end stage renal failure can improve strength and function.
Detailed description
Patients with chronic renal failure commonly have weak respiratory muscles leading to problems in everyday activities and respiratory infections. This project aims to investigate if threshold inspiratory muscle training improves the strength, everyday function and participation of patients on haemodialysis. Forty eight patients will be recruited in a randomized controlled trial of inspiratory muscle training vs sham training. Outcome measures include the maximal inspiratory pressure and the Frenchay activities index. Initial data will be collected by a blinded assessor; the patients will train at 40 % of initial maximal inspiratory pressure for six weeks and be reassessed. If the inspiratory muscle training is effective, it will improve both the physical and functional components of the patient's lives and be recommended for all renal patients.
Interventions
DEVICEInspiratory muscle training (URES HS730)
It will be set at 40% of the subjects baseline maximal inspiratory pressure and increased by 10% each week by an unblinded assistant. All subjects were trained with these devices for 8-10 breaths, 3 times a day, everyday for 6 weeks
DEVICESham inspiratory muscle training (URES HS730)
Subjects in the control group underwent sham training, using the same device with the diaphragm removed, thus providing no resistance. They were not given frequency or duration but told to use the device when desired.
Sponsors
The University of Queensland
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* documented chronic renal failure * attending either haemodialysis or pre-dialysis clinic * age 18 * English speaking * no prior experience with inspiratory training devices.
Exclusion criteria
* lung collagen disorders * renal diseases associated with autoimmune pulmonary diseases * current pleural effusion * pulmonary oedema * decreased conscious level * behavioural disturbances * unable or refused to give consent * taking medications that influence respiratory muscle function (e.g. steroids or cyclophosphamide)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximal inspiratory pressure (MIP) | Change between baseline (enrolment) and 6 weeks | American Thoracic Society standards |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frenchay activities index | Change between baseline (enrolment) and 6 weeks | The Frenchay activities index is a measure of instrumental activities of everyday living.The FAI assesses a broad range of activities associated with everyday life including social and family participation |
Countries
Australia
Outcome results
None listed