The Effect of Experimental Knee Pain During Strengthening Exercises on Muscle Strength Gain

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01346995

Enrollment

Registered

2011-05-04

Start date

2010-02-28

Completion date

2010-08-31

Last updated

2011-05-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Strength

Brief summary

The purpose of this study is to evaluate the effects of experimental knee pain on the muscle strength gain after 8 weeks of strengthening exercises for the quadriceps. It is hypothesized that experimental knee pain will reduce the muscle strength gain following strengthening exercises in healthy volunteers.

Interventions

OTHERExperimental knee pain

Injection of 1 ml hypertonic saline (5.8%) into the infrapatellar fat pad

OTHERNon-painful control injections

Injection of isotonic saline into the infrapatellar fat pad

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 35 Years

Healthy volunteers

Yes

Inclusion criteria

* aged between 20 to 35 years * healthy * untrained (non-regular exercise participation \[i.e. \< 1 day/week\])

Exclusion criteria

* symptomatic musculoskeletal diseases * history of traumatic injuries to muscles, tendons or joints of the lower extremity * knee joint pain within a month prior to enrollment

Design outcomes

Primary

Measure	Time frame
Isokinetic knee muscle strength	At baseline and after 8 weeks of exercise

Secondary

Measure	Time frame
One-leg chair rise	At baseline and after 8 weeks of exercise

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026