Polymorphisms of the Thiazide's Receptor Gene SLC12A3 and Development of Hyponatremia

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01346891

Enrollment

Registered

2011-05-03

Start date

2010-07-31

Completion date

Unknown

Last updated

2011-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Thiazide Diuretics Induced Hyponatremia

Brief summary

The purpose of this study is to detect if there are any differences in the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.

Detailed description

This is a Case Control study to compare the coding region of SLC12A3 gene in individuals who have had hyponatremia associated to the use of thiazides, and those thiazides consumers without hyponatremia that have demonstrated good tolerance to the drug.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients older than 21 years, belonging to one of the following groups: 1. Patients who have had Thiazide induced hyponatremia with serum sodium lower than 125 meq/L included in the Institutional Registry of Hyponatremia (Cases) 2. Patients with good tolerance to chronic treatment with Thiazides tha never had associated hyponatremia (Controls) 2. Patients with normal serum sodium measurements before the start of the Thiazides

Exclusion criteria

1. Refusal to participate or to the informed consent process 2. Unclear cause of hyponatremia, or other hyponatremia cause concomitant to Thiazide diuretics 3. Patients related to other individuals already included in the study

Countries

Argentina

Outcome results