Chronic Lymphocytic Leukemia
Conditions
Brief summary
This study aims to characterize clonal evolution in chronic lymphocytic leukemia (CLL) using different approaches and to identify a possible association with disease progression, i.e. therapy initiation. 1. Samples This monocentric study is carried out using representative bioarchived leukemic samples with a diagnosis of CLL, either at diagnosis or at evolution. These bioarchived samples were collected locally at our center during years of diagnostic activity, and were accurately pathologically, cytogenetically and molecularly characterized. 2. Clinical data The clinical data were retrospectively collected through collaboration with the referring physicians. 3. Methods Samples will be investigated by means of (1) conventional cytogenetics, (2) fluorescence in situ hybridization (FISH) and (3) SNP-arrays. After analysis of the array data sets, significant results will be validated and in addition, results will be correlated with clinical data.
Interventions
None listed
Sponsors
Universitaire Ziekenhuizen KU Leuven
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
0 Years to 130 Years
Healthy volunteers
No
Inclusion criteria
* diagnosis of CLL, * at least two available stored samples
Exclusion criteria
* at least one inclusion criterium not fulfilled
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time to therapy | baseline to day 1 of therapy | Time from diagnosis to the start of first line therapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Genetic abnormalities detected by karyotyping, FISH or array-analysis | 13-102 months | Detection of any type of genetic abnormality or pattern of abnormalities present at diagnosis or at time of disease progression (e.g. median 41 months after diagnosis, range 13-102 months) by means of karyotyping, fluorescent in situ hybridization or array-analysis. |
Countries
Belgium
Outcome results
None listed