Pain, Pain, Postoperative
Conditions
Brief summary
The primary aim of this study is to evaluate if multiple postoperative administrations with a solution of ropivacaine, ketorolac and epinephrine into the operating field through a catheter would affect morphine consumption. Secondary end-points are pain intensity, side effects and length of stay.
Interventions
DRUGropivacaine and ketorolac
The RK-group receives four intra-articular injections via catheter with a total volume of 40 ml (380 mg ropivacaine and 60 mg ketorolac) combined with 4 intravenous injections of saline during 24 hours postoperatively
DRUGKetorolac
The K-group receives four intra-articular injections via catheter with a total volume of 40 ml saline combined with 4 intravenous injections of ketorolac (total 60 mg) during 24 hours postoperatively
Sponsors
Lundbeck Foundation
University of Aarhus
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients scheduled for total hip arthroplasty * Patients \> 18 years of age * Signed written informed consent * Spinal anaesthesia
Exclusion criteria
* Allergy towards study drugs * Rheumatoid arthritis * Body Mass Index \> 35 (severe obesity) * Pregnancy or nursing women * Regular opioid use * Patients who can not read or understand danish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Morphine consumption | 24 hours postoperatively | Cummulative morphine comsumption postoperatively |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Pain intensity | 24 hours postoperatively | Pain intensity measured on the visual analog scale (VAS) at rest and during walking |
| Postoperative nausea | 24 hours postoperatively | Number of episodes of nausea measured on a 3 points rating scale (mild, moderate and severe) |
Countries
Denmark
Outcome results
None listed