The Correlation Between B-type Natriuretic Peptide (BNP) and Global End Diastolic Volume

The Correlation Between BNP and Global End Diastolic Volume

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01344265

Enrollment

Registered

2011-04-29

Start date

2010-06-30

Completion date

2011-10-31

Last updated

2013-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critically Ill

Keywords

B-type natriuretic peptide, global end diastolic volume

Brief summary

The investigators hypothesized that the serum B-type Natriuretic Peptide (BNP) level may be correlated with global end diastolic volume (GEDV) as measured by transpulmonary thermodilution technique (PiCCO). The rationale is that some animal studies have proven that BNP is released from ventricular myocardium in response to physical expansion. Such physical expansion can be measured by GEDV. If the hypothesis can be confirmed with our study, the serum level BNP can be used to monitor volume status of critically ill patient, instead of the invasive monitoring system.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* critically ill patients who required hemodynamic monitoring using PiCCO

Exclusion criteria

* patients with renal dysfunction * those older than 80 years * pregnant women

Design outcomes

Primary

Measure	Time frame	Description
global end diastolic volume	within 12 h after measurement of BNP	this is measured by transpulmonary thermodilution technique

Countries

China

Outcome results