Coronary Heart Disease, Type-2 Diabetes
Conditions
Brief summary
To investigate the effect of milk delivered from mountain-pasture grazing cows on risk markers of the metabolic syndrome and type-2 diabetes with the effect of conventional Danish milk. The study should reveal the importance of phytanic acid content for these effects.
Interventions
DIETARY_SUPPLEMENTmilk fat
39 g milk fat per day in 12 weeks
Sponsors
The Danish Dairy Research Foundation, Denmark
The Danish Council for Strategic Research
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* sign written consent * Age: 50-70 * BMI: 20-30 * increased risk of developing MS * refrain from dietary supplements and blood donations prior to, and during the study
Exclusion criteria
* poor compliance * if they suffering from any chronic or long lasting illness * abuse of alcohol or medicine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fatty acid composition in plasma | before and after the intervention (12 weeks) |
| Oral glucose tolerance test | before and after the intervention (12 weeks) |
| LDL cholesterol | before and after the intervention (12 weeks) |
| HDL cholesterol | before and after the intervention (12 weeks) |
| Total cholesterol | before and after the intervention (12 weeks) |
| Triacylglycerol | before and after the intervention (12 weeks) |
| C-reactive protein | before and after the intervention (12 weeks) |
Secondary
| Measure | Time frame |
|---|---|
| phytanic acid | before and after the intervention (12 weeks) |
Countries
Denmark
Outcome results
None listed