Genes, Omega-3 Fatty Acids and Cardiovascular Disease Risk Factors

Conditions

Cardiovascular Disease

Keywords

omega-3, PUFA, fatty acids, cardiovascular disease, gene expression

Brief summary

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors.

Detailed description

The main purpose of this study is to examine whether n-3 PUFA-induced changes in metabolic risk factors are influenced by genetic variations within genes acting as fatty acids sensors. To do so, the metabolic risk factor response to an n-e PUFA supplementation will be compared in carriers and non-carriers of polymorphism within genes acting as fatty acids sensors.

Matthew J. Picklo, Bastien Vallée Marcotte, Michael R. Bukowski, Juan de Toro‐Martín, Bret Rust et al. (7 authors)

Journal of the American Heart Association2021-01-195 citations

10.1161/jaha.120.018126

Fine mapping of genome-wide association study signals to identify genetic markers of the plasma triglyceride response to an omega-3 fatty acid supplementation.

Vallée Marcotte B, Guénard F, Lemieux S, Couture P, Rudkowska I, Calder PC, Minihane AM, Vohl MC.

2019-01-0114 citations

10.1093/ajcn/nqy298

Association between polymorphisms in phospholipase A2 genes and the plasma triglyceride response to an n-3 PUFA supplementation: a clinical trial

Bénédicte L. Tremblay, Hubert Cormier, Iwona Rudkowska, Simone Lemieux, Patrick Couture et al. (6 authors)

Lipids in Health and Disease2015-02-2038 citations

10.1186/s12944-015-0009-2

SREBF1 gene variations modulate insulin sensitivity in response to a fish oil supplementation

Annie Bouchard‐Mercier, Iwona Rudkowska, Simone Lemieux, Patrick Couture, Louis Përusse et al. (6 authors)

Lipids in Health and Disease2014-10-0113 citations

10.1186/1476-511x-13-152

Gene-diet interactions with polymorphisms of the MGLL gene on plasma low-density lipoprotein cholesterol and size following an omega-3 polyunsaturated fatty acid supplementation: a clinical trial

Catherine Ouellette, Iwona Rudkowska, Simone Lemieux, Benoı̂t Lamarche, Patrick Couture et al. (6 authors)

Lipids in Health and Disease2014-05-2418 citations

10.1186/1476-511x-13-86

Associations between dietary patterns and gene expression profiles of healthy men and women: a cross-sectional study.

Bouchard-Mercier A, Paradis AM, Rudkowska I, Lemieux S, Couture P, Vohl MC.

2013-02-1253 citations

10.1186/1475-2891-12-24

Interventions

DIETARY_SUPPLEMENTn-3 PUFA supplementation

3g per day of n-3 PUFA supplementation (1.9g EPA, 1.1g DHA). 5 capsules per day (1g fish oil each, 5g of fish oil/day)

Study design

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy men and women aged between 18 to 50 years; * having a BMI between 25 and 40kg/m2; * plasma triglycerides levels \<4.0 mmol/L; * non-smokers; * free of any thyroid or metabolic disorders requiring treatment such as diabetes, hypertension, severe dyslipidemia, and coronary heart disease.

Exclusion criteria

* subjects taking medication for hyperlipidemia, hypertension, diabetes or taking anticoagulant or n-3 PUFA supplementation; * having a taste aversion for fish, fish allergy or regular alcohol drinker; * body mass index \> 40kg/m2; * pregnant or nursing women.

Design outcomes

Primary

Measure	Time frame
Change in blood lipids (Total cholesterol, HDL-Cholesterol, Triglycerides)	Before and after a 6-weeks supplementation

Secondary

Measure	Time frame
Change in blood pressure	Before and after a 6-weeks supplementation
Change in anthropometric measures (waist and hip girth)	Before and after a 6-weeks supplementation
Change in plasma glycemia and insulin levels	Before and after a 6-weeks supplementation
Change in gene expression levels	Before and after a 6-weeks supplementation

Countries

Canada

Contacts

PRINCIPAL_INVESTIGATORMarie-Claude Vohl, Ph.D.

Institute of Nutraceutical and Functional Foods (INAF), Laval University

Outcome results

None listed