Sarcoma
Conditions
Keywords
metastatic childhood soft tissue sarcoma, nonmetastatic childhood soft tissue sarcoma, recurrent childhood soft tissue sarcoma, previously treated childhood rhabdomyosarcoma, previously untreated childhood rhabdomyosarcoma, recurrent childhood rhabdomyosarcoma
Brief summary
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer. PURPOSE: This research trial is studying biomarkers in samples from young patients with soft tissue sarcoma.
Detailed description
OBJECTIVES: * To identify the key components of driver pathways of primary and secondary soft tissue sarcomas. * To perform the next-generation sequencing on primary versus normal on undifferentiated sarcomas. OUTLINE: Genomic DNA and RNA samples from undifferentiated sarcoma tumors are analyzed by next-generation sequencing for somatic mutations. Normal matched lymphocytes and tissue are also analyzed.
Interventions
GENETICDNA analysis
GENETICRNA analysis
GENETICmutation analysis
GENETICnucleic acid sequencing
OTHERlaboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No
Inclusion criteria
DISEASE CHARACTERISTICS: * Banked childhood samples from the COG-D9902 soft tissue sarcoma biology and banking study * Rhabdomyosarcoma, NOS PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of somatic mutations in driver genes and mutations in other genes that occur individually | — |
Outcome results
None listed