The Effect of Metformin on the Correlation Between Hyperinsulinemia and Hypertension

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01342614

Enrollment

140

Registered

2011-04-27

Start date

2006-05-31

Completion date

2009-08-31

Last updated

2011-05-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diabetes Mellitus, Essential Hypertension

Keywords

Hypertension, Insulin Resistance, Hyperinsulinemia, Metformin, Fosinopril

Brief summary

The objective of this study is to investigate the effect of metformin on the correlation between hyperinsulinemia and hypertension.

Interventions

DRUGFosinopril

Fosinopril group received fosinopril, 10mg, once per day.

DRUGMetformin

Metformin group was treated with metformin hydrochloride, 500mg, three times per day

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 65 Years

Healthy volunteers

Inclusion criteria

* 20 to 65 years of age, regardless of sex * duration of hypertension was \<5 years * overweight or obesity, mild to moderate hypertension, receive no euglycemic agent or antiobesity drug

Design outcomes

Primary

Measure	Time frame
Blood pressure measurement	8 weeks

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026