Subclassification of the Syndrome of Inappropriate ADH Secretion

Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01341665

Enrollment

Registered

2011-04-26

Start date

2008-03-31

Completion date

2011-04-30

Last updated

2011-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyponatremia

Keywords

hyponatremia, SIADH, copeptin

Brief summary

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH. These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* age \> 18 years, * hyponatremia \< 132 mmol/L * SIADH

Exclusion criteria

* age \< 18 years * cerebral metastases * serum sodium \> 132mmol/L

Countries

Germany

Outcome results