Perioperative/Postoperative Complications
Conditions
Keywords
Remote ischemic preconditioning, Abdominal surgery, Perioperative complications
Brief summary
Major abdominal surgeries are associated with perioperative cardiac morbidity of up to 10%. Ischemic preconditioning may have a protective effect. The purpose of this study is to find out remote ischemic conditioning by inflating a blood pressure cuff on the arm will have a protective effect.
Interventions
PROCEDURERemote Ischemic Pre-conditioning
Cuff placed on arm. Three 5- minute cycles of blood pressure cuff inflation: cuff is inflated to 200 mm Hg for 5 minutes followed by a 5-minute deflation (reperfusion.)
PROCEDUREControl
Cuff placed on arm uninflated for 30 minutes.
Sponsors
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients undergoing abdominal surgery:large bowel, pancreatic and hepatic surgery
Exclusion criteria
* Chronic inflammatory disease. * Glyburide use before surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular Events: incidence of MI, TIA/stroke, death in both groups | One week |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Renal function deterioration in the first week after surgery | One week | Baseline Creatinine levels will be compared to the highest creatinine levels noted in the first 7 days of hospitalization |
Countries
Canada
Outcome results
None listed