Post Operative Inflammatory Marker Levels
Conditions
Keywords
ketamine, inflammatory, pro inflammatory, pro inflammatory markers IL-6 and IL-1beta
Brief summary
. Null Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will not have a reduction effect on the levels of IL-6 & IL-1β pro inflammatory markers by 48 hours. . Alternate Hypothesis: Giving low doze ketamine (0.5mg/kg) given preoperatively to adult patients undergoing elective surgery, in Mulago hospital, will have a reduction effect on the levels of IL-6 & IL-1β pro inflammatory markers by 48 hours.
Detailed description
RESEARCH QUESTION Can 0.5mg/kg of Ketamine given preoperatively have an effect on the levels of pro-inflammatory markers? Primary specific Outcome: changes/deviations from baseline levels of IL- 6 pro-inflammatory markers of after surgery at PACU, 24 and 48 hours. Secondary specific Outcome: changes/deviations from baseline levels of IL-1β pro-inflammatory markers of after surgery at PACU, 24 and 48 hours.
Interventions
DRUGKetamine
determining the effect of low dose sub anesthetic doze of ketamine and placaebo on post operative patients
Sponsors
Makerere University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Consented patients due for elective surgery * Adult patients 18- 70 year old * ASA I- ASA II scoring patients, who are normal patients or those with mild systemic illness
Exclusion criteria
* Emergency cases that will already have high levels of inflammatory markers secreted in their system by incision time e.g. road traffic accidents * Patients with chronic / severe hypertension * Febrile Patients (T \>38°C) * Persistently raised blood pressures above 140/90 for 2 consistent readings 15 minutes apart * Patients with pheochromocytoma * Spinal and local infiltration anaesthesia cases * Neuro surgery patients whom Ketamine is contra indicated * Epilepsy patients * ASA IIIE and above * Patients receiving Aspirin prophylaxis * Chronic inflammatory disease states such as hyperparathyroidism
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes/deviations from baseline levels of IL-6 pro-inflammatory markers of after surgery | 48 hours | changes/deviations from baseline levels of IL-6 pro-inflammatory markers of after surgery at Post Anesthesia Care Unit, 24 and 48 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes/deviations from baseline levels of IL-1β pro-inflammatory markers of after surgery | 48 hours | changes/deviations from baseline levels of IL-1β pro-inflammatory markers of after surgery at PACU, 24 and 48 hours |
Countries
Uganda
Outcome results
None listed