Anesthetic Ventilatory Requirements
Conditions
Keywords
Quantification, ventilatory requirements, charcoal filter
Brief summary
The anesthesia gas reflector (AnaConDa) is built on the adsorptive capacity of active carbon which also adsorbs carbon dioxide in exhaled air. Rebreathing of carbon dioxide thus occurs and must be compensated for by increased ventilation. This study aims at determining how much compensation must be given, based on the hypothesis that rebreathing depends on carbon dioxide level in blood and exhaled air.
Interventions
DEVICEAnesthetic Conserving Device (AnaConDa )
Standard HME was replaced by AnaConDa. AnaConDa has charcoal filter, HME does not.
Sponsors
Region Skane
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* elective coronary artery by-pass graft surgery * elective valve replacement surgery * normal left ventricular ejection fraction on preoperative echocardiography
Exclusion criteria
* obstructive lung disease * restrictive lung disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas. | 1 hour | A conventional heat and moisture exchanger used in a respiratory circuit during anasthesia was exchanged by an AnaConDa. The AnaConDa causes re-breathing of carbon dioxide which clinically is equivalent to an increased airway dead space. The total airway dead space effect of the AnaConDa, i.e. volume of the device plus rebreathing from the charcoal filter was measured using the Single Breath Test for carbon dioxide, as was airway deadspace of the conventional Heat and Moisture Exchanger. Airway dead space differences between devices was calculated by subtraction of volumes thus achieved. Difference= Airway dead space AnaConDa - Airway dead space conventional Heat and Moisture Exchanger. |
Countries
Sweden
Participant flow
Recruitment details
September 2011 to January 2013, Medical Clinic
Pre-assignment details
All recruited patients participated uneventfully.
Participants by arm
| Arm | Count |
|---|---|
| All Study Participants Heat and Moisture Exchanger, then AnaConDa, finally Heat and Moisture Exchanger | 6 |
| Total | 6 |
Baseline characteristics
| Characteristic | All Study Participants |
|---|---|
| Age, Categorical <=18 years | 0 Participants |
| Age, Categorical >=65 years | 2 Participants |
| Age, Categorical Between 18 and 65 years | 4 Participants |
| Age, Continuous | 63 years |
| Region of Enrollment Sweden | 6 participants |
| Sex: Female, Male Female | 1 Participants |
| Sex: Female, Male Male | 5 Participants |
Adverse events
| Event type | EG000 affected / at risk |
|---|---|
| deaths Total, all-cause mortality | — / — |
| other Total, other adverse events | 0 / 6 |
| serious Total, serious adverse events | 0 / 6 |
Outcome results
Primary
Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas.
A conventional heat and moisture exchanger used in a respiratory circuit during anasthesia was exchanged by an AnaConDa. The AnaConDa causes re-breathing of carbon dioxide which clinically is equivalent to an increased airway dead space. The total airway dead space effect of the AnaConDa, i.e. volume of the device plus rebreathing from the charcoal filter was measured using the Single Breath Test for carbon dioxide, as was airway deadspace of the conventional Heat and Moisture Exchanger. Airway dead space differences between devices was calculated by subtraction of volumes thus achieved. Difference= Airway dead space AnaConDa - Airway dead space conventional Heat and Moisture Exchanger.
Time frame: 1 hour
| Arm | Measure | Value (MEDIAN) |
|---|---|---|
| AnaConDa | Airway Dead Space With Devices for Heat and Moisture Exchange of Respiratory Gas. | 136 mL |