The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture

The Effect of Vitamin c on Preventing Complex Regional Pain Syndrome (CRPS Type I) Following Ankle Fracture, Prospective Double Blind Study

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01338129

Acronym

CRPS

Enrollment

100

Registered

2011-04-19

Start date

2011-04-30

Completion date

2014-02-28

Last updated

2011-04-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ankle Fracture

Keywords

vitamin c, ascorbic acid, ankle fracture, crps, rds, crps prevention

Brief summary

The use of prophylactic treatment with vitamin c may prevent complex regional pain syndrome (CRPS)

Detailed description

There are several studies similar in wrist fracture.

Interventions

DIETARY_SUPPLEMENTvitamin c

1000 mg of vitamin c for 45 days

DRUGplacebo

placebo pills

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

TRIPLE (Subject, Caregiver, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* ankle fracture within 3 weeks after the fracture

Exclusion criteria

* pregnant or lactating woman * open fracture * already treated with vitamin c * chronic renal failure

Design outcomes

Primary

Measure	Time frame	Description
CRPS incidence	6 months	the incidence of CRPS (according to the IASP or Bruehl diagnostic cruteria) in both population following the fracture will be record and compared

Countries

Israel

Contacts

Primary Contactalon burg, MD

alonb@clalit.org.il972-54-4854248

Backup Contacteli sidon, MD

elisid@clalit.org.il972-52-3896169

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026