Hematopoietic Stem Cell Transplant, Total-body Irradiation
Conditions
Keywords
Fecal biomarkers, Radiation biodosimetry, Total-body irradiation (TBI), Hematopoietic stem cell transplantation, Gene expression profiles, Fecal metabolites
Brief summary
The purpose of this study is to develop fecal tests that will determine the extent of radiation exposure in patients undergoing radiation treatment for cancer. This project will determine whether fecal biomarkers can be used to diagnose exposure to radiation.
Detailed description
Patients undergoing TBI as part of a hematopoietic stem cell transplant (HSCT) will have feces collected for use in the validation and refinement of new methods for rapid radiation biodosimetry. The stool samples will be collected before, and at defined times after TBI. Stool sampling will occur in the same manner that it does during routine patient care during HSCT.
Interventions
None listed
Sponsors
Medical College of Wisconsin
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
2 Years to 21 Years
Healthy volunteers
No
Inclusion criteria
* All races are eligible * 2 years to 21 years old * Must be undergoing hematopoietic stem cell transplantation (either autologous or allogeneic) in conjunction with a conditioning regimen that includes total-body irradiation (TBI) (single or multiple fraction).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To describe changes in gene expression associated with exposure to radiation | prior to TBI treatment (baseline) and up to 2 weeks following the last dose of TBI | Changes in gene expression will be measured as abundance of RNA levels relative to the weight of feces |
Countries
United States
Outcome results
None listed