Gastric Residuals in Preterm Infants

Gastric Residuals in Preterm Infants (GRIP)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01337622

Enrollment

Registered

2011-04-19

Start date

2011-03-31

Completion date

2013-12-31

Last updated

2015-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Early Enteral Feeding Advancement, Nutrition, Preterm Infants

Brief summary

Checking of gastric residuals prior to the continuation/increase of enteral feeding prolongs the time to establish full gastric feeding in the early postnatal period.

Interventions

PROCEDURENo check of gastric residuals for early enteral feeding advancement

Discontinuation of gastric feeding and its advancement will be based on clinical examination of the abdomen and gastric aspirates containing blood or significant vomiting.

PROCEDURERoutine check of gastric residuals for early enteral feeding advancement

Discontinuation of gastric feeding and its advancement will be based on current practice of clinical examination of the abdomen and checking residual before every feed. Volume and color of gastric residual will be considered according to the current guideline.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 48 Hours

Healthy volunteers

Inclusion criteria

* Infants with a birth weight ≥ 1500g and \< 2000g * Age ≤48 hours of life * Informed, written parental consent

Exclusion criteria

* Antenatally recognized gastrointestinal malformation * Major congenital anomaly * Chromosomal anomaly * NEC stage II * Severe acidosis, asphyxia (pH \<7.0) * Severe growth restriction below 3rd percentile

Design outcomes

Primary

Measure	Time frame	Description
Time to reach full enteral feeding	from inclusion (during first 48h of life) until 1 month	Full enteral feeding is defned as an milk intake of equal or more than 120 ml/kg/d.

Secondary

Measure	Time frame	Description
growth, tolerance, morbidity	from inclusion (during first 48h of life) until one month	Time to regain birth weight and maintain weight gain. Incidence of sepsis from birth until 48 hours after parenteral nutrition was administered. Use of antibiotics. Incidence of feeding intolerance and necrotizing enterocolitis.

Countries

Canada

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 6, 2026