Childhood Hepatoblastoma, Stage I Childhood Liver Cancer, Stage II Childhood Liver Cancer, Stage III Childhood Liver Cancer, Stage IV Childhood Liver Cancer
Conditions
Brief summary
This research trial is studying biomarkers in tissue samples from young patients with liver cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
Detailed description
PRIMARY OBJECTIVES: I. To identify biomarker signatures associated with hepatoblastoma subtypes (by microRNA array profiling), and their potential correlation with liver developmental stages as well as outcome. II. To correlate expression array data with copy number array data. SECONDARY OBJECTIVES: I. To carry out a focused sequencing interrogation of amplified or deleted genomic regions as well as genes in key cell pathways involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma. II. To perform whole exome sequencing in a subset of tumors. OUTLINE: This is a multicenter study. Archived tumor tissue samples are analyzed for hepatoblastoma and other liver tumor biomarkers by microRNA array profiling and exome sequencing. Results are then compared with patients' clinical data.
Interventions
GENETICRNA analysis
GENETICgene expression analysis
GENETICmicroarray analysis
GENETICnucleic acid sequencing
OTHERdiagnostic laboratory biomarker analysis
Sponsors
National Cancer Institute (NCI)
Children's Oncology Group
Study design
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
No minimum to 16 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of hepatoblastoma or other liver cancer including the following subtypes: * Pure fetal histology * Transitional histology * Small cell undifferentiated histology * Participated on the Children's Oncology Group (COG) clinical trials * Available data and tumor samples
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarkers associated with hepatoblastoma subtypes and cancer stages | Baseline |
Secondary
| Measure | Time frame |
|---|---|
| Genes involved in embryonic development and/or stem cell signaling pathways for which preliminary data suggests involvement in the pathogenesis of hepatoblastoma | Baseline |
| Exome sequencing | Baseline |
Countries
United States
Outcome results
None listed