Community Acquired Pneumonia
Conditions
Brief summary
This is a descriptive clinical research aiming: * To describe the clinical spectrum and clinical characteristics of community acquired pneumonia (CAP) in patients admitted to hospital * To identify the etiology of CAP and the antibiotic sensitivity of the isolated organisms * To identify the risk factors that influence the severity of CAP
Detailed description
In Vietnam, the range and relative contribution of organisms causing CAP remain unclear, largely because diagnostic tools are limited and clinical research uncommon. An improved understanding of the risk factors, etiology and clinical outcomes of CAP in Vietnam would contribute to improved approaches to patient diagnosis and clinical management. This will be achieved by following the clinical and laboratory progress and treatment outcomes of in-patients diagnosed with CAP from admission to discharge. Comparative analyses will be between subgroups including survivor and non-survivor, severe CAP and non-severe CAP, known etiology and unknown etiology, SIRS, sepsis, severe sepsis and shock septic.
Interventions
None listed
Sponsors
Oxford University Clinical Research Unit, Vietnam
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients \> or = 18 years of age * Patient meets the criteria of pneumonia (below), established within 36h of hospitalization * Patient is not hospitalized or residing in a long-term-care facility within 14 days before the onset of symptoms * Patient has not been at a referral hospital for \>2 days before admission to the study hospital * Informed consent to participate in the study is provided
Exclusion criteria
* Severe immunosuppression as judged by the enrolling physician (e.g. HIV, leukemia, lymphoma, chemotherapy for solid tumors, long-term corticosteroid use or other immunosuppressive drugs) * Known active tuberculosis or current treatment for tuberculosis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of patients who are stable at Day 3, 7 and 14 | up to 14 days | • Criteria for clinical stability * Temperature \< or = 37.8oC * Heart rate \< or = 100 beats/min * Respiratory rate \< or = 24 breaths/min * Systolic blood pressure \> or = 90 mm Hg * Arterial oxygen saturation \> or = 90% or pO2 \> or = 60 mm Hg on room air * Ability to maintain oral intake * Normal mental status |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Length of ventilation time | participants will be followed for the duration of hospital stay, an expected average of 2 weeks | — |
| Day 14 mortality | 14 days | Proportion of patients who die at Day 14 |
| Length of stay (days) | participants will be followed for the duration of hospital stay, an expected average of 2 weeks | Length of stay from admission to discharge in days |
| Need for mechanical ventilation | participants will be followed for the duration of hospital stay, an expected average of 2 weeks | — |
Countries
Vietnam
Outcome results
None listed