Main Branch Versus Side Branch Ostial Lesion

Relationship Between Fractional Flow Reserve and Coronary Angiography/Intravascular Ultrasound Parameters in Ostial Lesions: Major Coronary Ostial Lesions Versus Side Branch Ostial Lesions

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01335659

Enrollment

Registered

2011-04-14

Start date

2010-06-30

Completion date

2011-06-30

Last updated

2011-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Stenosis

Keywords

FFR, IVUS, QCA

Brief summary

The investigators studied the relations between coronary angiography (CAG), intravascular ultrasound (IVUS) and fractional flow reserve (FFR) in coronary ostial lesions.

Detailed description

Angiographic evaluation for ostial lesions is reported to be inaccurate in the assessment of the functional and clinical significance of a lesion. The investigators studied the relations between coronary angiography (CAG), intravascular ultrasound (IVUS) and fractional flow reserve (FFR) in coronary ostial lesions.

Interventions

DEVICEFractional flow reserve

Fractional flow reserve measured by pressure wire

DEVICEIVUS

intravascular ultrasound :IVUS was performed in a standard fashion using an automated motorized pullback system (0.5mm/s) with commercially available imaging catheter

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 85 Years

Healthy volunteers

Inclusion criteria

* Age 21-85 * Presence of at least one obstructive coronary artery stenosis at coronary ostium as defined by: * Previous catheterization with any coronary ostium lesion 50% or greater * Ability and Willingness to provide informed consent * Ability and Willingness to perform required follow up procedures

Exclusion criteria

* History of coronary artery bypass graft surgery * left main coronary ostial lesion * significant stenosis at proximal or distal part of coronary ostium lesion * ostial lesion related to infarcton * Creatinine\>1.6 mg/dL or GFR\<30 pre-procedure per institutional standards * Ejection fraction lower than 40% * Known Pregnancy * Arrhythmia * Contrast agent allergy that cannot be adequately premedicated * Patient not a candidate for IVUS and FFR * Inability or unwillingness to provide informed consent * Inability or unwillingness to perform required follow up procedures

Design outcomes

Primary

Measure	Time frame	Description
lumen area	1 day	lumen area at ostial lesion

Secondary

Measure	Time frame	Description
angiographic stenosis, % plaque area	1 day	angiographic and intravascular ultrasound parameters at ostial lesions of each major branch and side branch.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Mar 26, 2026