Endometriosis
Conditions
Keywords
minimal to mild endometriosis, letrozole, clomiphene citrate, IUI
Brief summary
To evaluate pregnancy rates with letrozole and CC alone in an IUI program for women with recently surgically treated minimal to mild endometriosis.
Interventions
DRUGLetrozole/IUI
Patients received 5 mg letrozole daily for 5 days. A single insemination was performed 32-36 hours after hCG (10,000 IU, IM). Patients underwent up to four cycles of treatment.
DRUGCC/IUI
Patients received 100 mg lCC daily for 5 days. A single insemination was performed 32-36 hours after hCG (10,000 IU, IM). Patients underwent up to four cycles of treatment.
Sponsors
Mansoura University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
20 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* Patient with minimal-mild endometriosis recently treated by laparoscopy with a waiting period of 6 to 12 months following the procedure * No other infertility factors. * Normal serum basal hormone levels as well as documented ovulation
Exclusion criteria
* Moderate or severe endometriosis * Dense adnexal and/or ovarian adhesions due to pelvic inflammatory disease or previous pelvic surgery * Age more than 36 years, BMI more than 30 kg/m2 * women with a previous pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate per cycle | 6-7 weeks gestation |
Secondary
| Measure | Time frame |
|---|---|
| Miscarriage rate. | Up to 20 weeks gestation |
Countries
Egypt
Outcome results
None listed