ST-elevation Myocardial Infarction, (STEMI)
Conditions
Keywords
ST-elevation myocardial infarction(STEMI), emergency percutaneous coronary intervention(PCI), lipitor or Atorvastatin
Brief summary
The purpose of this study is to evaluate the clinical effect of intensive statin therapy before emergency PCI in patients with STEMI.
Detailed description
150 STEMI patients planned for emergency PCI were randomized to three groups, Group 1:received atorvastatin 80-mg loading dose before PCI then followed by 40-mg daily for one month and a maintenance dose of 20-mg qd thereafter(n=50); Group 2:received atorvastatin 40-mg qd after PCI for one month and a maintenance dose of 20-mg qd thereafter(n=50); Group 3: received atorvastatin 20-mg qd after PCI (n=50).Before PCI,all subjects received oral administration of aspirin 300mg and clopidogrel 300mg.Levels of creatine kinase,CK-MB(creatine kinase-MB),were measured to estimate myocardial damage degree.HS-CRP(high sensitivity C -reactive protein),NO(NO synthase),SAA(Serum amyloid A) were measured at preoperation 1 hour,postoperative 24 and 72 hours,7days after PCI. To compare echocardiography changes among three groups.Patients enrolled in the study need to receive follow-up survey which was carried out by clinical doctors.Hence,MACEs were analyzed during 6-month follow-up.So, the aim of our study is to evaluate the clinical significance of loading dosage of atorvastatin therapy and analyze the mechanism underlying it.
Interventions
DRUGAtorvastatin
Group 1:80mg before PCI and 40mg per day after PCI for one month then 20mg per day until the end of the trial Group 2:40mg per day after PCI for one month then 20mg per day until the end of the trial Group 3:20mg per day after PCI until the end of the trial
Sponsors
General Hospital of Chinese Armed Police Forces
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* 1.Clinical diagnosis of STEMI less than 12 hours 2.Eligible for emergency PCI
Exclusion criteria
* 1.Contradiction to atorvastatin 2.Contradiction to aspirin, clopidogrel and contrast medium 3.Life expectancy less than 3 months 4.Tumor or inflammatory diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| MACEs (Major adverse cardiac events) | follow-up for 6 months | MACEs were compared among three groups during follow-up in STEMI patients undergoing emergency PCI. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Echocardiographic changes | postoperative 6 month | to compare echocardiographic changes ( left ventricular ejection fraction(LVEF); Left Ventricular Internal Diameter diastolic(LVIDd);Left Ventricular Internal Diameter systolic (LVIDs),Left Ventricular Enddiastolic Volume(LVEDV);Left Ventricular Endsystolic Volume(LVESV)at postoperative 6 month among three groups |
| HS-CRP,NO,SAA values | preoperation 1 hour,postoperative 24 and 72 hours,postoperative 7 days | to compare hs-crp,no,saa values at differnt treatment period among three groups |
| CK,CK-MB | preoperation 1hour,postoperation 4/8/12/16/20/24hours | to estimate myocardial damage degree among three groups |
| AST(glutamic-oxalacetic transaminease ),ALT(glutamic-pyruvic transaminase),LDL(low density lipoprotein cholesterin),TG(triglyceride) | preoperation 1 hour,postoperation 24 and 72hours,postoperation 7 days | to monitor adverse drug reaction |
Countries
China
Contacts
Primary ContactHuiLiang LIU, Doctor
Backup ContactYong Yang, Doctor
Outcome results
None listed