Upper Extremity Injury Trauma
Conditions
Keywords
Anesthetic techniques,regional, Drug delivery,volume, Anesthetic, local: ropivacaine
Brief summary
The retrograde infraclavicular brachial plexus block has been proved an effective and safe approach. Realtime ultrasound guide will facilitate a successful peripheral nerve block. The purpose of this study was to determine the medium effective volume required to produce an effective retrograde infraclavicular block using an ultrasound (US)-guided technique.
Detailed description
Thirty adults undergoing elective upper limb surgery received an US-guided retrograde infraclavicular block. The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. The effective volume in 95% of patients (EV95) was calculated using probit regression.
Interventions
PROCEDUREappropriate volume of 0.5% ropivacaine
initial concentration: 30 ml, subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient, until 5 up-and-down cycles completed.
Sponsors
Beijing Jishuitan Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Elected upper extremity operations * BMI 17\ 30kg/m2 * ASA I/II
Exclusion criteria
* Infection at injection site * Sepsis * Coagulation Dysfunction * Phrenic nerve palsy * Pneumothorax * Recurrent laryngeal nerve palsy * Clavicle fracture combined with nerve damage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS of brachial plexus innervated area | 20 minutes | effect and side effects of the present block approach for brachial plexus. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| medium effective ropivacaine volume | about 2 months | The initial concentration of 0.5% ropivacaine injected was 30 ml, which was subsequently varied at a ratio of 1: 1.2 for each consecutive patient according to the response of the previous patient. The medium effective volume (EV50) was determined using the Dixon and Massey up-and-down method. EV95 was calculated using probit regression. |
Countries
China
Outcome results
None listed