Coronary Artery Disease
Conditions
Keywords
CABG surgery, exercise intervention, insulin sensitivity, muscle mass
Brief summary
In this study, the investigators want to examine the impact of coronary artery bypass graft (CABG) surgery on skeletal muscle mass, muscle metabolism, and insulin sensitivity in 90 subjects. In extent, the impact of a subsequent exercise intervention will be examined, with a follow-up up to 12 months after surgery.
Detailed description
90 subjects undergoing elective CABG surgery will be included. These subjects are free from orthopedic limitations, will have no severe complications during surgery, and are willing to participate in a 12-week exercise training intervention. At baseline (before surgery), following parameters will be assessed: blood parameters (glycemic control, lipid profile, anabolic/catabolic hormones, inflammatory markers), body composition (by dual x-ray absorptiometry), handgrip strength, and general subject features (medication, gender, age, etc.). The first three days after surgery, blood samples will be collected for the analysis of glycemic control, lipid profile, anabolic/catabolic hormones, inflammatory markers. Next, at the start of exercise intervention, after 6 and 12 weeks of exercise training, and after a 12-month follow-up, following parameters will be assessed: blood parameters (glycemic control, lipid profile, anabolic/catabolic hormones, inflammatory markers), body composition (by dual x-ray absorptiometry), handgrip strength, maximal exercise capacity (by ergospirometry testing), physical activity (by questionnaire), and quality of life ( by questionnaire). At 12 months of follow-up, cardiovascular mortality and morbidity (re-occurrence of angina, acute myocardial infarction, need for surgery, death) will be assessed. When initiating exercise intervention, subjects will randomly (n=30 in each group) be assigned to 12 weeks of standard exercise intervention (endurance exercise training), modified exercise intervention (endurance exercise training + strength training), or modified exercise intervention (endurance exercise training + strength training + oral protein supplements). This will be a cluster randomized clinical trial. Investigators executing the measurements will be blinded for treatment allocation.
Interventions
OTHERexercise training
endurance exercise training: 40 min of exercise at 65% of VO2peak, 3 days/week
Sponsors
Hasselt University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Elective CABG surgery * Willing to participate in 12-week exercise intervention
Exclusion criteria
* Complicated surgery * Severe complications during first days after CABG surgery * Orthopedic limitations that interfere with proper exercise intervention participation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| change in muscle mass and insulin sensitivity | pre-operative, 1, 2, 3 days, and 2, 12, 54 weeks after surgery | Baseline insulin sensitivity and muscle mass will be assessed ahead of surgery. Afterwards, the change in these parameters will be assessed at various predefined timepoints. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| change in exercise capacity | 2, 12, 54 weeks after surgery | Baseline exercise capacity will be assessed at 2 weeks after surgery. Afterwards, the change in this parameters will be assessed at various predefined timepoints. |
Countries
Belgium
Outcome results
None listed