Breast Cancer, Healthy
Conditions
Keywords
No metastatic breast cancer, cognitive troubles, adjuvant chemotherapy
Brief summary
The purpose of this study is to investigate memory problems in patients with cancer.
Interventions
PROCEDUREcognitive tests and cerebral IRM
cognitive tests and cerebral IRM
Sponsors
Centre Francois Baclesse
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
45 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
for patients: * Patients aged 45 and over * Patients from Grade 3 'end of primary schooling minimum (scale Barbizet) * Non-Metastatic Breast Cancer * Adjuvant Chemotherapy: FEC, including Docetaxel Protocols * No major cognitive impairment * No previous neurological * Lack of personality disorders and psychiatric disorders evolutionary * Having signed the informed consent of study participation Inclusion Criteria for control group: * Women from the general population aged 45 and over, and matched in age and cultural level in patients * Topics of Grade 3 'end of primary schooling minimum (scale Barbizet) * No prior cancer * No major cognitive impairment * No previous neurological * Lack of personality disorders and psychiatric disorders evolutionary * Participating in the IMAP Protocol No. ID-BCR: 2007-A00414-49 or IMAP+(n° ID RCB 2011-A01493-38)(see how the study below) have signed forms no objection and consent to study participation
Exclusion criteria
Traduction (français \> anglais) * Metastatic * Cancer of the breast other than primitive * Patients with paraneoplastic syndrome * Patients under 45 years * Patients whose achievement is below level 3 'end of primary schooling (scale Barbizet) * Patients with adjuvant chemotherapy is associated with targeted therapy * Patients who have received other cancer treatments (chemotherapy or radiotherapy brain) * Contraindication to the implementation of an MRI (claustrophobia, metal objects in the body) * disorders of higher functions existing in the administration of chemotherapy * Neurologic earlier * Pathology psychiatric evolutionary * Refusal of participation * Patients unable to meet the cognitive tests * Drug use * Heavy drinking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Assess the relationship between memory impairment and brain dysfunction | Before chemotherapy (baseline), end of chemotherapy and follow-up up to 12 months after chemotherapy | The main objective is to assess the relationship between memory impairment and brain dysfunction in patients treated with adjuvant chemotherapy for breast cancer (before and after treatment), compared to a group of healthy subjects. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Impact of age | Before chemotherapy (baseline), end of chemotherapy and follow-up up to 12 months after chemotherapy | The secondary objective is to assess the impact of age on the extent of memory impairment. |
Countries
France
Outcome results
None listed