Obesity
Conditions
Keywords
Obesity, Weight loss, Ghrelin, Satiety, Hunger
Brief summary
EFFECT OF HIGH CARBOHYDRATE AND HIGH PROTEIN BREAKFAST ON WEIGHT LOSS, GHRELIN, HUNGER AND CRAVING SCORES IN OBESE MEN AND WOMEN. D Jakubowicz, M Boaz, J Wainstein, O Froy Background: Obesity underlying endocrine, metabolic and eating behaviour features promotes weight gain, increase of hunger, and carbohydrate (Carb) craving. Restrictive diets either in calories or Carb produce withdrawal effect, that further exacerbate Carb craving resulting in rapid return of obesity. Meal timing and composition has shown to play a pivotal role in appetite regulation through several hormonal systems such as ghrelin. The investigators hypothesized that to be successful; a weight loss strategy must change the hormonal environment to increase satiety while reducing hunger and craving. Objectives: To assess weight loss, satiety, hunger, cravings and ghrelin response to two isocaloric diets. Additionally, these outcomes were measured in response to meal challenge. Methods: In this randomized, treatment controlled clinical trial, 146 obese, sedentary adults with impaired glucose tolerance will be assigned to Low carb diet (LCHbd) or an isocaloric diet with a high carb, high protein breakfast (HCPbd),1400 kcal for women and 1600 kcal for men. LCHbd breakfast will provide 300 kcal with carb: protein: fat of 13:40:48. HCPbd breakfast will provide 600 kcal with 50:20:30. From baseline until week 16 participants will take part in a supervised weight loss diet, followed until week 32 by a maintenance period. Anthropometric measures, OGTT for glucose and insulin, VAS-measured hunger and satiety and Food Craving Inventory Analysis will be performed at baseline, week 16 and week 32.
Interventions
BEHAVIORALEnriched breakfast
high carbohydrate, high protein breakfast supplying 600 kcal as 50k% carbohydrate, 20% protein, 30% fat
BEHAVIORALControl breakfast
Control breakfast providing 300 kcal, 13% carbohydrate, 40% protein, 48% fat
Sponsors
Wolfson Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
25 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* adult * male and female * obese * sedentary * glucose intolerant/insulin resistant
Exclusion criteria
* pregnant/lactating * malignancy * taking weight loss medications * know eating disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weight loss | 32 weeks | Change from baseline weight |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Hunger | 32 weeks | VAS hunger scores |
| Satiety | 32 weeks | VAS satiety scores |
| plasma ghrelin | 32 weeks | change from baseline ghrelin |
Countries
Israel
Contacts
Primary ContactDaniela Jakubowicz, MD
Backup ContactJulio Wainstein, MD
Outcome results
None listed