Septic Shock, Severe Sepsis
Conditions
Keywords
microcirculation, SDF, magnesium sulfate
Brief summary
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.
Detailed description
In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.
Interventions
DRUGMagnesium Sulfate
2 gram in 1 hour
Sponsors
Lithuanian University of Health Sciences
Frisius Medisch Centrum
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* severe sepsis and septic shock
Exclusion criteria
* pregnancy * oral bleeding * age \< 18 years * liver cirrhosis * acute arrhythmias * advanced malignancy or a mean arterial pressure (MAP) \< 65 mmHg refractory to vasopressors
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| microvascular flow index | 1 hour | Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained. |
Countries
Lithuania
Outcome results
None listed