Chronic Rhinosinusitis
Conditions
Brief summary
This research study will be completed by enrolling a prospective, observational cohort study to evaluate medical versus surgical treatment outcomes for chronic sinus disease. This investigation will compare quality of life outcomes between each treatment type, as well as measure cellular and molecular markers of inflammation in the sinus mucosa, to create models that predict improvement in quality of life following treatment.
Interventions
None listed
Sponsors
National Institute on Deafness and Other Communication Disorders (NIDCD)
Oregon Health and Science University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Adult (\>= 18 years) * Chronic rhinosinusitis as defined by the 2007 multi-disciplinary adult sinusitis guidelines * Able to complete all surveys/questionnaires in English * Persistent symptoms following initial medical management * Received at least 1 course of broad spectrum antibiotics or culture directed antibiotics for at least a total of 14 days * Received at least a 3 week trial of topical steroid sprays OR at least a 5 day trial of systemic corticosteroid therapy. * Counseled for subsequent treatment options including either medical management or endoscopic sinus surgery
Exclusion criteria
* Children (\<18 years) * Unable to complete all surveys/questionnaires at baseline
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Disease-specific quality of life | 18 months post-treatment |
Secondary
| Measure | Time frame |
|---|---|
| General health-related quality-of-life | 18 months post-treatment |
| Olfaction | 18 months post-treatment |
Countries
United States
Outcome results
None listed