Pain, Postoperative
Conditions
Brief summary
Our study will compare the use of continuous saphenous nerve block performed at the adductor canal in addition to Local Infiltration Analgesia (LIA) versus a Sham block in addition to LIA for total knee replacement. The investigators hypothesize that the saphenous nerve block performed at the level of the adductor canal in addition to LIA provides better pain relief than the LIA alone without significantly compromising muscle strength and physiotherapy, enabling patients to mobilize early with reduced opioid consumption and les side effects. The investigators will enroll a total of 40 patients (20 patients will receive continuous saphenous nerve block in addition to LIA and 20 will receive the sham block and LIA). Until discharge, the investigators will record patients' pain scores, opioid consumption, side effects and physical therapy progress. If our study proves that the continuous saphenous nerve block in addition to LIA can effectively reduce postoperative pain scores to an acceptable level with better physical therapy progress and less opioid consumption, it could be seen as a more attractive alternative to LIA alone or other traditionally used methods of postoperative pain control that compromises muscle strength and physiotherapy.
Interventions
PROCEDUREcontinuous saphenous nerve block
Postoperative intermittent boluses of 15 Ml Ropivacaine 7,5 mg/Ml every 12 hours for three days
PROCEDURESaline boluses in nerve catheter
A nerve catheter will be placed in the adductor canal using saline instead of Ropivacaine for intermittent boluses.
Sponsors
Henning Lykke Andersen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-III * Age: 40-75 * Unilateral TKA * Use of Spinal anesthesia
Exclusion criteria
* Allergy to any of the study medications * Intolerance to morphine * Contraindication to a spinal anesthetic * Intraoperative use of any volatile anesthetic * Chronic opioid use * ASA Class 4-5 * Rheumatoid arthritis or Diabetes mellitus with neuropathy * Liver or kidney failure * BMI above 40 * Severe COPD
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pain scores | 3 days postoperative | VAS pain scores |
Secondary
| Measure | Time frame |
|---|---|
| Opioid consumption | 3 days postoperative |
| physical therapy progress | 3 days postoperative |
Countries
Denmark
Outcome results
None listed