Effect of Rapid Transfusion With Fluid Management System (FMS) on Plasma Potassium in Liver Transplantation Recipients

Potassium Change in the Fluid Management System (FMS) Reservoir and Its Effect on the Plasma Potassium Concentration During Liver Transplantation Surgery

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT01331889

Enrollment

Registered

2011-04-08

Start date

2011-10-31

Completion date

2016-04-30

Last updated

2016-07-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Condition Requiring Rapid Transfusion During Liver Transplantation Surgery

Keywords

transfusion, liver transplantation, potassium

Brief summary

Rapid infusion of red blood cells is known to result in hyperkalemia in the body. However, potassium concentration in the blood mixture (usually made of RBC, FFP and normal saline) in the reservoir of rapid infusion system and its effect on the plasma potassium change during rapid transfusion are unknown. This study is designed to investigate these changes while massive transfusion is performed during liver transplantation surgery.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

19 Years to 80 Years

Healthy volunteers

Inclusion criteria

* preoperative anemia (hemoglobin \< 10 g/dl) * preoperative coagulopathy

Exclusion criteria

* children under age 18 * low risk of intraoperative bleeding

Design outcomes

Primary

Measure	Time frame	Description
potassium concentration in the Fluid Management System (FMS) reservoir	after transfusion of 150 ml of blood mixture	During bolus transfusion (300ml) of blood mixture, blood sample is taken from the side port of infusion line of Fluid Management System (FMS) when 150 ml of blood mixture was transfused. Because the priming volume of the internal circuit is approximately 100 ml, blood sample that was taken after 150 ml transfusion represents the content in the reservoir.

Secondary

Measure	Time frame	Description
plasma potassium of the patient	before and after transfuison of 300 ml of blood mixture	Just before transfusion starts, blood samples are taken from the central venous catheter and arterial line at the same time to measure baseline values. At the immediate end of transfusion, blood samples are taken again from the same sites to measure the resultant changes.

Countries

South Korea

Outcome results