Obsessive Compulsive Disorder
Conditions
Keywords
Cognitive and Behavioral Therapy
Brief summary
Obsessive compulsive Disorder (OCD) is a frequent psychiatric disorder. Obsessions and compulsions are the two manifestations of this disease. Obsessions are recurrent anxious ideas, and compulsions repetitive behavior aiming to decrease this anxiety. OCD symptoms have been associated with cortical and sub-cortical dysfunctions and more precisely an hyperactivity of prefrontal cortex / basal ganglia loops. Functional neuro-imagery studies have shown a significant decrease of orbito-frontal cortex, anterior cingulate cortex, caudate nucleus and cerebellum activities after two OCD reference treatments : medication and Cognitive and Behavioral Therapy (CBT). Two groups of 20 patients are included in this study and follow a CBT for 15 sessions. They are randomised in two groups : one proposing a reference CBT, the other associate CBT to a new psychopedagogic task developed by the investigators team. Clinical investigations and neuro-imagery data are collected at the main steps of therapies : before, during (half-therapy), at the end of therapies and 6 month later. Symptoms severity, patients and relatives quality of life are also assessed.
Interventions
BEHAVIORALCognitive and behavioral Therapy
15 CBT sessions with a psychologist expert in OCD treatment
Sponsors
Institut National de la Santé Et de la Recherche Médicale, France
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Age between 18 and 65; * Following Obsessive Compulsive Disorder criteria according to DSM IV(300.3 ;MINI 5.0.0); * OCD severity range from 20 to 30 on the Y-Brown obsessive compulsive scale; * Having checking symptoms; * Understanding and accepting the study; * Giving his written informed consent to the study.
Exclusion criteria
* Claustrophobia; * Cerebral abnormality; * Chronic absenteism to CBT (more than 5 missed sessions during the whole therapy). In case of exclusion of the study either decided by the patient himself or by the investigator, a debriefing is proposed by a psychologist.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in brain activity associated with different types of Cognitive Behavioral Therapy Obsessive Compulsive Disorder | before CBT, at half CBT (1.5 month), after CBT (3 months) and 6 six months later | Evaluation and comparison of changes in brain activity associated with different types of Cognitive Behavioral Therapy in patients with Obsessive Compulsive Disorder |
Countries
France
Outcome results
None listed