Sterility
Conditions
Brief summary
To assess the effectiveness of protocols of ovarian hyperstimulation combining urinary gonadotrophins + GnRH antagonist vs urinary gonadotrophins, to achieve clinical pregnancy in females undergoing intrauterine insemination. Study hypothesis: protocols combining urinary gonadotrophins + GnRH antagonist should be more effective than monotherapy.
Interventions
DRUGhMG-HP
DRUGhMG + GnRH antagonist
Sponsors
Ferring SAU
Ferring Pharmaceuticals
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 36 Years
Healthy volunteers
No
Inclusion criteria
* Women aged 18-36 years * Body mass index (BMI) between 18 and 26 * Prolactin within the laboratory normal range * Couples affected by sterility able to treat by IUI (intrauterine insemination) * Patients undergoing Menopur® treatment * Normal thyroid function * Regular menses (21-35 days) * Couples willing to participate in the study that have signed the informed consent form * Seminal sample REM\>3 million
Exclusion criteria
* Two previous ART (assisted reproductive technology) cycles without ongoing pregnancy * Policystic ovarian syndrome * Evidence of significant bacterial infection in the seminogram of the couple in the preceding 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical pregnancy rate | 30 days |
Secondary
| Measure | Time frame |
|---|---|
| Live birth rate | 40 weeks |
Countries
Spain
Outcome results
None listed