Kidney Stones, Nephrolithiasis, Urolithiasis
Conditions
Keywords
Kidney stones, Calcium, citrate
Brief summary
Beverages containing citrate may be useful in increasing urine citrate content and urine pH. Such changes in urine chemistry could help prevent kidney stones. Diet orange soda has more citrate than other similar beverages. The investigators are interested in whether diet soda will improve urine chemistry in the appropriate manner.
Detailed description
The effect of orange soda compared with water in changing 24 hour urine citrate excretion in mg/day will be determined.
Interventions
DIETARY_SUPPLEMENTOrange soda
32 ounces per day
Sponsors
VA New York Harbor Healthcare System
Study design
Allocation
NON_RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-65 years old * able to sign consent * ability to reliably urinate into a vessel and measure urine volume
Exclusion criteria
* prior history of nephrolithiasis * a known history of metabolic bone disease * hyperthyroidism * hyperparathyroidism or chronic kidney disease * current use of diuretics * current use of potassium citrate or other oral alkali supplementation and * use of calcium supplementation that could not be stopped
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in urine citrate content | 1 week | Citrate is measured in 24h urine sample and expressed as mg/day |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in urine pH | One week | urine pH is measured in a 24h urine sample and has no units |
Countries
United States
Outcome results
None listed