Acute Nonarteritic Anterior Ischemic Optic Neuropathy
Conditions
Brief summary
In this study 16 Patients diagnosed with Nonarteritic Anterior Ischemic Optic Neuropathy(NSION) who had a sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn in less than 30 days without exclusion criteria are randomly divided in two groups 1) control 2) case. In case group Avastin and Triamcinolone will be injected trough vitreal and placebo will be injected in control group. BCVA and Visual field will be then measured in these two groups.
Interventions
DRUGAvastin and Triamcinolone
1.25 mg Avastin and 2mg Triamcinolone will be injected trough vitreal
OTHERplacebo
2mg placebo
Sponsors
Shahid Beheshti University of Medical Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Sudden mono ocular vision loss associated with optic disc edema and positive Marcus Gunn (\<30 days)
Exclusion criteria
* Any eye disease except NAION(Nonarteritic Anterior Ischemic Optic Neuropathy) * Neurologic defect * Abnormal ESR, CRP, any history of retina or vitreal surgery * Severe corneal opacity which makes retina examination impossible
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of Best corrected visual acuity(BCVA) | 6 month | outcome method of measurement: Snellen chart |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes of Visual Field | 6 month | Automated perimeter |
Countries
Iran
Outcome results
None listed