Cerebrovascular Disorders, Dementia
Conditions
Keywords
stroke, Brain ischemia, Intracranial hemorrhage, Dementia, Vascular, Alzheimer's disease
Brief summary
If the risk of dementia occurrence after stroke is well known, few data exist about the factors influencing positively or negatively the developement of cognitive disorders or dementia. The aim of the study is so to determine prospectively the clinical, biological, lesional and pharmacological factors associated with post-stroke dementia by the long-term follow-up of a stroke patient cohort.
Detailed description
The STROKDEM study is based on the 5-year prospective follow-up of a population of 1100 stroke patients without dementia. At inclusion in the cohort, main antecedents and risk factors, previous treatment and lifestyle, initial severity and etiology are recorded. Biological samples (for standard ans specialized analyses) and MRI are performed at 72h after stroke occurrence. Thereafter, patients are regularly (6 months, 12 months, 36 months, 60 months) examined for clinical and cognitive assessment with biological samples and Magnetic Resonance Imaging. Patients with dementia will be compared to patients without stroke to identify, by logistic regression analysis and Cox model, the factors associated with dementia occurrence.
Interventions
None listed
Sponsors
Ministry of Health, France
University Hospital, Lille
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 95 Years
Healthy volunteers
No
Inclusion criteria
* patients \> 40 years olds * hemispheric stroke * stroke dating from less 72h * IQ-code \< 64 * patient (or his family) given an informed consent
Exclusion criteria
* non hemispheric stroke * malformative intracranial hemorrhage * traumatic intracranial hemorrhage * subarachnoidal hemorrhage * contra-indication to MRI * patients unable to answer to cognitive battery
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| dementia occurrence | 60 months | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient and his/her family. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| dementia occurrence and cognitive impairment | 6 months | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient and his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living |
| dementia occurence and cognitive impairment | 36 months | This evaluation will be based on a neurological and general clinical examination, and on the evaluation of activities of daily life using the Instrumental Activities Daily Life scale after an interview with the patient ans his/her family. Impairment of some tests of cognitive battery without significant impairment in activities of daily living |
| cognitive impairment | 36 months | Impairment of some tests of cognitive battery without significant impairment in activities of daily living |
Countries
France
Outcome results
None listed