Early Administration of Bifidobacterium to Very Low Birth Weight Infants

Early Administration of Bifidobacterium Bifidum to Very Low Birth Weight Infants: A Pilot Study

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01330095

Enrollment

Registered

2011-04-06

Start date

2007-03-31

Completion date

2008-12-31

Last updated

2011-04-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Infants

Keywords

Bifidobacterium bifidum, Very low birth weight infant, Enteral feeding, Growth, amount of enteral feeding

Brief summary

To evaluate the effects of early administration of probiotics on acceleration of enteral feeding, and on growth of very low birth weight infants, newborn infants with birth weight less than 1500g are administered Bifidobacterium bifidum twice a day.

Interventions

DIETARY_SUPPLEMENTAdministration of Bifidobacterium bifidum

Administration of Bifidobacterium bifidum to very low birth weight infants

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

No minimum to 7 Days

Healthy volunteers

Inclusion criteria

* Very low birth weight infant

Exclusion criteria

* Presence of major congenital malformations

Design outcomes

Primary

Measure	Time frame	Description
the day at total feeding volume reached 100ml/kg/day	post natal day	the post natal day at total enteral feeding reached 100ml/kg/day

Secondary

Measure	Time frame	Description
colonizatin of Bifidobacterium	4 weeks after birth	the level of Bifidobacterium in feces from the study infants growth rate of the study infants the positive rate of MRSA colonization among the study infants adverse outcomes

Countries

Japan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026