Kidney Calculi
Conditions
Keywords
Potassium sodium citrate, stone recurrence, ESWL, PCNL, Hypocitraturia, intervention
Brief summary
Extracorporeal shock wave lithotripsy (ESWL) and Percutaneous nephrolithotomy (PCNL) become the therapy of choice for renal stone. Although providing good results, stone recurrence is usually found as the therapies do not change the underlying metabolic abnormality. Among the metabolic disorders, hypocitraturia is an important risk factor for calcium nephrolithiasis. This study evaluate the preventive effects of potassium sodium citrate on stone recurrence as well as stone growth post ESWL or PCNL, in patients with calcium-containing stones.
Interventions
DRUGPotassium-sodium citrate
The treated group was given oral potassium-sodium citrate 81 mEq/day The control group received no treatment
Sponsors
Chiang Mai University
Prince Songkla University
Chulalongkorn University
Siriraj Hospital
Ouiheng International Healthcare Co., Ltd
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* age \> 18 years * stone free or had residual calcium oxalate stone fragments with a less than 4 mm. diameter at eight weeks after ESWL or PCNL
Exclusion criteria
* renal tubular obstruction * serum creatinine \> 2 mg/dl * urinary tract infection (bacteria \> 100,000 in urine culture) * hypersensitive or contraindication to Potassium sodium hydrogen citrate * insertion Double-J Stent * history of arrhythmia, myocardial infarction or digitalis administration
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| rate of stone recurrence or stone growth | 12 months | The patients were evaluated at 6 months after the initial treatment for serum chemistry and urinalysis. After 12 months, all patients were evaluated for serum chemistry, urinalysis, 24-hour urine study and plain KUB. |
Outcome results
None listed