Healthy
Conditions
Keywords
glycerophosphates, sphingomyelins
Brief summary
The aim of the study is to investigate parameters of the lipid metabolism in plasma and feces of healthy subjects after a dietary supplementation of different dosages of milk phospholipids.
Detailed description
To date the mechanisms for the intestinal absorption of glycerophosphates and sphingolipids are not completely investigated. It is assumed, that sphingolipids and sterols compete for intestinal absorption. In addition it is unclear, if a dietary phospholipid supplementation may influence the phospholipid concentration in plasma. To evaluate the effect of a dietary phospholipid supplementation 15 healthy female subjects received over 10 days daily 3 g of milk phospholipids stirred in a dairy product. During the following 10 days the subjects were supplemented with daily 6 g milk phospholipid. Finally, the subjects received over 10 days 6 g of the milk phospholipid in a dairy product and 2 g of plant sterols serving a commercial product.
Interventions
DIETARY_SUPPLEMENTMilk phospholipid
During day 1 until 10 the subjects were supplemented with daily 3 g milk phospholipids, during the day 11 and 20 the supplementation was increased to daily 6 g, and during the day 21 and 30 the subjects received daily 6 g milk phospholipids and 2 g of plant sterols.
Sponsors
University of Jena
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* female * age: between 30 and 45 years
Exclusion criteria
* metabolic diseases * arteriosclerosis * pregnancy and breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in plasma phospholipid concentration | after 0, 10, 20, and 30 days | Total phospholipid concentration Individual phospholipid concentration (lyso phosphatidylcholine, phosphatidylcholine, sphingomyelin, phosphatidylethanolamine, phosphatidylinositol) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Plasma lipids | after 0,10,20, and 30 days | Fatty acid fraction (total fatty acid distribution, phospholipid fatty acid distribution) Cholesterol fraction (total cholesterol, LDL cholesterol, HDL cholesterol) Triacylglycerides fraction |
| Fecal lipids | after 0,10,20, and 30 days | Fecal lipids (crude fat, total phospholipids, sterols, bile acids) |
Countries
Germany
Outcome results
None listed