Acute Lung Injury, Acute Respiratory Distress Syndrome, Respiratory Failure
Conditions
Keywords
electrical impedance tomography, positive end-expiratory pressure, regional ventilation delay index
Brief summary
The purpose of this study in patients suffering from acute lung injury is to determine whether positive end-expiratory pressure (PEEP) setting guided by electrical impedance tomography (EIT) influences pulmonary gas exchange, lung mechanics, ventilation/perfusion matching and homogeneity of regional ventilation when compared to other PEEP setting strategies such as the open lung concept or the ARDSnet protocol.
Interventions
PROCEDUREPEEP titration
PEEP is set according to the following protocols, respectively, in a randomized order: ARDSnet table, Open Lung strategy, guided by EIT
Sponsors
University Hospital, Bonn
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* acute lung injury, need for optimization of ventilatory settings
Exclusion criteria
* preexisting chronical lung disease, pneumothorax, pace maker, hemodynamical instability, increased intracranial pressure
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| homogeneity of regional ventilation delay | up to eight hours | influence of different PEEP titration strategies on homogeneity of regional ventilation delay measured by electrical impedance tomography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| pulmonary gas exchange, lung mechanics and ventilation/perfusion matching | up to eight hours | influence of different PEEP titration strategies on pulmonary gas exchange, lung mechanics and ventilation/perfusion matching |
Countries
Germany
Contacts
Primary ContactChristian Putensen, Prof., MD
Backup ContactThomas Muders, MD
Outcome results
None listed