Improvement of Anorectal Function While Preserving of Inferior Mesenteric Artery Performing Left Hemicolectomy for Diverticulosis

Effect of Inferior Mesenteric Artery Preservation Performing Left Hemicolectomy for Diverticulosis in the Anorectal Function

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT01326052

Acronym

IPIMAL

Enrollment

150

Registered

2011-03-30

Start date

2004-01-31

Completion date

2011-12-31

Last updated

2012-06-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Defecatory Disorders After Left Colonic or Rectal Resection

Brief summary

The aim of the study is to evaluate the anorectal function after hemicolectomy if we preserve or not the Inferior Mesenteric Artery (IMA). This study wants to demonstrate that IMA preservation could improve patient's quality of life reducing incontinence and/or constipation rate.

Interventions

PROCEDUREInferior Mesenteric Artery Preservation

Performing left hemicolectomy the IMA was preserved ligating close to the colonic wall the sigmoids arteries.

PROCEDUREInferior Mesenteric Artery Ligation

Performing left hemicolectomy the IMA is ligated and sectioned after the origin of left colic artery

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* Age from 18 to 80 years * BMI\<35 * Presence of symptomatic diverticular disease * ASA I-III

Exclusion criteria

* age \> 80 years * BMI\>35 * ASA IV * Hinchey III-IV * Past performed procedure that could be modify the nervous pattern (i.e. colorectal surgery, left nephrectomy, hysteroannessectomy)

Design outcomes

Primary

Measure	Time frame	Description
Change from preoperative time in anorectal function	6 and 12 months	We evaluate the presence of modification in anorectal function respect to the preoperative time. This is assessed with specific questionnnaires and anorectal manometry

Secondary

Measure	Time frame	Description
Constipation	6 and 12 months	We evaluate with a questionnaire (Constipation scoring system) the presence of postoperative constipation
Incontinence	6 and 12 months	We evaluate with a questionnaire (Continence scale), anorectal manometry and eventually with endoanal ultrasonography the precence of incontinence
Quality of life	6 and 12 months	We evaluate with SF-36 questionnaire the postoperative quality of life
Postoperative complication	1 month	We evaluate the presence of postoperative complication such as anastomotic leakage, anastomotic stricture, pneumonia etc.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026